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- Giovanni Solinas
Giovanni Solinas
Professor
Department of Molecular and Clinical MedicineProfessor
Department of Molecular and Clinical MedicineAbout Giovanni Solinas
Professor, Principal Investigator
Giovanni Solinas moved to the Wallenberg Laboratory from the University of Fribourg, Switzerland, in 2014. He is currently professor of molecular medicine in the Department of Molecular and Clinical Medicine. His team investigates the molecular mechanisms underlying the metabolic stress associated with obesity and the role of these mechanisms in the pathogenesis of obesity and obesity-induced type 2 diabetes and tumor promotion.
Honors
- 2013 European Foundation for the Study of Diabetes (EFSD). Diabetes and Cancer Research Programme Award.
- 2012 Prix de la Fondation Endocrinologie Geneve.
- 2010 European Foundation for the Study of Diabetes (EFSD). Diabetes and Cancer Research Programme Award.
- 2009 European Foundation for the Study of Diabetes, EFSD/Lilly Research Fellowship Award.
- 2008 Novartis Research Foundation Research Grant.
- 2007 Roche Research Foundation Startup Fellowship.
- 2004 American Diabetes Association (ADA) Mentor Based Post-Doctoral Fellowship.
- 2003 Swiss National 91̽ Foundation (SNSF) Post-Doctoral Fellowship for Prospective Investigators.
- 1996 University of Milan “Summa cum Laude”.
Background
- 1996 MSc University of Milan (Italy).
- 2002 PhD in Biochemistry at the University of Fribourg (Switzerland).
- 2002-2003 Post-doctoral research associate, Division of Physiology, University of Fribourg.
- 2003-2007 Post-doctoral fellow, Department of Pharmacology, University of California, San Diego (USA).
- 2007-2014 Assistant Professor in Molecular Physiology, Department of Medicine, University of Fribourg (Switzerland).
- 2014 Professor of Molecular Medicine, The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University 91̽ (Sweden).
Group members
- Barbara Becattini, PhD, Senior Scientist
- Arianna Mazzoli, PhD Student
- Angela Molinaro, PhD Student
Key Publications
- Molinaro Angela; Becattini B.; Mazzoli A.; Bleve A.; Radici L.; Maxvall I.; Rotter Sopasakis V.; Molinaro Antonio; Bäckhed F.; Solinas G.* Insulin-Driven PI3K-AKT Signaling in the Hepatocyte is Mediated by Redundant PI3Ka and PI3Kb Activities and is Promoted by RAS. Cell Metabolism 2019 June 4;29(6):1400-1409.
- Bousquenaud M.; Fico F.; Solinas G; Rüegg C.; and Santamaria-Martínez A. Obesity promotes the expansion of metastasis-initiating cells. 2018 Breast Cancer Research 2018 Sep 4;20(1):104.
- Giovanni Solinas and Barbara Becattini The role of PI3Kγ in metabolism and macrophage activation Oncotarget, 2017, Vol. 8, (No. 63), pp: 106145-106146 Breasson L, Sardi C, Becattini B, Zani F, Solinas G. PI3Kγ ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic β-cell apoptosis. FASEB J. 2017 Sep 13. pii: fj.201700372RR. doi:
- Breasson L, Becattini B, Sardi C, Molinaro A, Zani F, Marone R, Botindari F, Bousquenaud M, Ruegg C, Wymann MP, Solinas G. PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity. Sci Signal. 2017 Jul 18;10(488). pii: eaaf2969. doi: 10.1126/scisignal.aaf2969.
- Solinas G, Becattini B. JNK at the crossroad of obesity, insulin resistance, and cell stress response. Mol Metab. 2016 Dec 8;6(2):174-184. doi: 10.1016/j.molmet.2016.12.001. eCollection 2017 Feb. Review.
- Becattini B, Zani F, Breasson L, Sardi C, D'Agostino VG, Choo MK, Provenzani A, Park JM, Solinas G. JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage. FASEB J. 2016 Sep;30(9):3124-32. doi: 10.1096/fj.201600393R. Epub 2016 May 26.
- Solinas G, Borén J, Dulloo AG. De novo lipogenesis in metabolic homeostasis: More friend than foe? Mol Metab. 2015 Mar 20;4(5):367-77. doi: 10.1016/j.molmet.2015.03.004. eCollection 2015 May. Review.
- Zani F, Breasson L, Becattini B, Vukolic A, Montani JP, Albrecht U, Provenzani A, Ripperger JA, Solinas G. PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G L expression. Mol Metab. 2013 Jul 1;2(3):292-305. doi: 10.1016/j.molmet.2013.06.006. eCollection 2013. Wymann M, Solinas G. Inhibition of phosphoinositide 3-kinase γ attenuates inflammation, obesity, and cardiovascular risk factors. Ann NY Acad Sci 1280:44-47 (2013)
- Zani F, Breasson L, Becattini B, Montani JP, Provenzani A, Albrecht U, Ripperger JA, Solinas G. Mol Metab 2:292-395 (2013)
- Marcelino H, Veyrat-Durebex C, Summermatter S, Sarafian D, Miles-Chan J, Arsenijevic D, Zani F, Montani JP, Seydoux J, Solinas G, Rohner-Jeanrenaud F, Dulloo AG. A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth: a Randle cycle favoring fat storage. Diabetes 62:362-372 (2013)
- Solinas G. Molecular pathways linking metabolic inflammation and thermogenesis. Obes Rev 13 (Suppl 2):69-82 (2012)
- Becattini B, Marone R, Zani F, Arsenijevic D, Seydoux J, Montani JP, Dulloo AG, Thorens B, Preintner F, Wymann MP, Solinas G. Proc Natl Acad Sci USA 108:E854-E863 (2011)
- Holzer RG, Park EJ, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147:173-184 (2011)
- Solinas G, Karin M. JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J 24: 2596-2611 (2010)
- Summermatter S, Marcelino H, Arsenijevic D, Buchala A, Aprikian O, Assimacopoulos-Jeannet F, Seydoux J, Montani JP, Solinas G, Dulloo AG. Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: relevance for muscle-adipose glucose redistribution during catch-up growth. Diabetes 58:2228-2237 (2009)
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Barbara Becattini, Andrea Usseglio Gaudi, Per-Anders Jansson, Giovanni Solinas
METABOLISM-CLINICAL AND EXPERIMENTAL - 2025 -
Angela Molinaro, Arianna Mazzoli, Andrea Usseglio Gaudi, Amit Chand Gupta, Vagner Ramon Rodrigues Silva, Damien Ramel, Muriel Laffargue, Johan Ruud, Barbara Becattini, Giovanni Solinas
ISCIENCE - 2025 -
Giovanni Solinas, Barbara Becattini
Trends in endocrinology and metabolism - 2024 -
Bettina Mittendorfer, James D Johnson, Giovanni Solinas, Per-Anders Jansson
Diabetes - 2024 -
Barbara Becattini, Angela Molinaro, Marcus Henricsson, Jan Borén, Giovanni Solinas
Cell reports - 2024 -
Linda Engström-Ruud, Ferran Font Gironès, Joanna Zajdel, Lara Kern, Júlia Teixidor-Deulofeu, Louise Mannerås Holm, Alba Carreras, Barbara Becattini, Andreas Björefeldt, Eric Hanse, Henning Fenselau, Giovanni Solinas, Jens C Brüning, Thomas F Wunderlich, Fredrik Bäckhed, Johan Ruud
Cell reports - 2024 -
Giovanni Solinas, Barbara Becattini
Current topics in microbiology and immunology - 2022 -
Eileen Dahlke, Toni Engmann, Yaman Anan, Robert Häsler, Giovanni Solinas, Franziska Theilig
International journal of molecular sciences - 2022 -
Vagner Ramon Rodrigues Silva, Angela Molinaro, Andrea Usseglio Gaudi, Emanuel Fryk, Claudia Sardi, Maria Hammarlund, Filip Mjörnstedt, Maria E Johansson, Barbara Becattini, Per-Anders Jansson, Giovanni Solinas
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2022 -
Arianna Mazzoli, Claudia Sardi, Ludovic Breasson, Franziska Theilig, Barbara Becattini, Giovanni Solinas
FASEB bioAdvances - 2021 -
Emanuel Fryk, Josefin Olausson, Karin Mossberg, Lena Strindberg, M. Schmelz, Helén Brogren, L. M. Gan, S. Piazza, A. Provenzani, Barbara Becattini, L. Lind, Giovanni Solinas, Per-Anders Jansson
Ebiomedicine - 2021 -
Barbara Becattini, Ludovic Breasson, Claudia Sardi, F. Zani, Giovanni Solinas
Jhep Reports - 2021 -
Angela Molinaro, Barbara Becattini, Giovanni Solinas
Scientific Reports - 2020 -
Andrea Caddeo, Oveis Jamialahmadi, Giovanni Solinas, Puija Arturo, Rosellina Margherita Mancina, Piero Pingitore, Stefano Romeo
Journal of structural biology - 2019 -
Angela Molinaro, Barbara Becattini, Arianna Mazzoli, Augusto Bleve, Lucia Radici, Ingela Maxvall, Victoria Rotter Sopasakis, Antonio Molinaro, Fredrik Bäckhed, Giovanni Solinas
Cell Metabolism - 2019 -
M. Bousquenaud, F. Fico, Giovanni Solinas, C. Ruegg, A. Santamaria-Martinez
Breast Cancer Research - 2018 -
Toshima Z Parris, Elisabeth Werner Rönnerman, Hanna Engqvist, Jana Biermann, Katarina Truvé, Szilard Nemes, Eva Forssell-Aronsson, Giovanni Solinas, Anikó Kovács, Per Karlsson, Khalil Helou
Oncotarget - 2018 -
Ludovic Breasson, Claudia Sardi, Barbara Becattini, Fabio Zani, Giovanni Solinas
Faseb Journal - 2018 -
Ludovic Breasson, Barbara Becattini, Claudia Sardi, Angela Molinaro, Fabio Zani, Romina Marone, Fabrizio Botindari, Mélanie Bousquenaud, Curzio Ruegg, Matthias P Wymann, Giovanni Solinas
91̽ signaling - 2017 -
Giovanni Solinas, Barbara Becattini
Molecular Metabolism - 2017 -
Giovanni Solinas, Barbara Becattini
Oncotarget - 2017 -
Barbara Becattini, Fabio Zani, Ludovic Breasson, D'Agostino Vito, Claudia Sardi, Min-Kyung Choo, Alessandro Provenzani, Jin-Mo Park, Giovanni Solinas
The FASEB Journal - 2016 -
Giovanni Solinas, Jan Borén, A. G. Dulloo
Molecular Metabolism - 2015 -
Fabio Zani, Ludovic Breasson, Barbara Becattini, Jean-Pierre Montani, Alessandro Provenzani, Urs Albrecht, Juergen Ripperger, Giovanni Solinas
Molecular Metabolism - 2013 -
Matthias P Wymann, Giovanni Solinas
Annals of the New York Academy of 91̽s - 2013 -
Helena Marcelino, Christelle Veyrat-Durebex, Serge Summermatter, Delphine Sarafian, Jennifer Miles-Chan, Denis Arsenijevic, Fabio Zani, Jean-Pierre Montani, Josiane Seydoux, Giovanni Solinas, Abdul G. Dulloo
Diabetes - 2013 -
Giovanni Solinas
Obesity reviews : an official journal of the International Association for the Study of Obesity - 2012 -
Xiaozhe Zhang, Filomena Petruzziello, Fabio Zani, Laetitia Fouillen, Per E. Andren, Giovanni Solinas, Gregor Rainer
Journal of Proteome Research - 2012 -
Ryan G. Holzer, Eek-Joong Park, Ning Li, Helen Tran, Monica Chen, Crystal Choi, Giovanni Solinas, Michael Karin
Cell - 2011 -
Barbara Becattini, Romina Marone, Fabio Zan, Denis Arsenijevic, Josiane Seydoux, Jean-Pierre Montan, Abdul G. Dulloo, Bernard Thorens, Frédéric Preitner, Matthias P. Wymann, Giovanni Solinas
Proceedings of the National Academy of 91̽ of the United States of America - 2011 -
Giovanni Solinas, Michael Karin
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2010 -
A G Dulloo, J Jacquet, Giovanni Solinas, J-P Montani, Y Schutz
International journal of obesity (2005) - 2010 -
Hwanju Cheon, Jae Min Cho, Sunshin Kim, Seung-Hoon Baek, Moon-Kyu Lee, Kwang-Won Kim, Seong-Woon Yu, Giovanni Solinas, Soung Soo Kim, Myung-Shik Lee
Molecular and Cellular Endocrinology - 2010 -
Serge Summermatter, Helena Marcelino, Denis Arsenijevic, Antony Buchala, Olivier Aprikian, Françoise Assimacopoulos-Jeannet, Josiane Seydoux, Jean-Pierre Montani, Giovanni Solinas, Abdul G. Dulloo
Diabetes - 2009 -
John L. Stebbins, Surya K. De, Thomas Machleidt, Barbara Becattini, Jesus Vazquez, Christian Kuntzen, Li-Hsing Chen, Jason F. Cellitti, Megan Riel-Mehan, Aras Emdadi, Giovanni Solinas, Michael Karin, Maurizio Pellecchia
Proceedings of the National Academy of 91̽ of the United States of America - 2008 -
Giovanni Solinas, Cristian Vilcu, Jaap G Neels, Gautam K Bandyopadhyay, Jun-Li Luo, Willscott Naugler, Sergei Grivennikov, Anthony Wynshaw-Boris, Miriam Scadeng, Jerrold M Olefsky, Michael Karin
Cell Metabolism - 2007 -
Giovanni Solinas, Serge Summermatter, Davide Mainieri, Marcel Gubler, Jean-Pierre Montani, Josiane Seydoux, SR Smith, Abdul G Dulloo
Endocrinology - 2006 -
Lufen Chang, Hideaki Kamata, Giovanni Solinas, Jun-Li Luo, Shin Maeda, K Venuprasad, Yun-Cai Liu, Michael Karin
Cell - 2006 -
Giovanni Solinas, Willscott Naugler, Francesco Galimi, Myung-Shik Lee, Michael Karin
Proceedings of the National Academy of 91̽ of the United States of America - 2006 -
Giovanni Solinas, Serge Summermatter, Davide Mainieri, Marcel Gubler, Luciano Pirola, Matthias P Wymann, Sandro Rusconi, Jean-Pierre Montani, Josiane Seydoux, Abdul G Dulloo
FEBS letters - 2004 -
A G Dulloo, M Gubler, J P Montani, J Seydoux, Giovanni Solinas
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 2004 -
Abdul G Dulloo, Michael J Stock, Giovanni Solinas, Olivier Boss, Jean Pierre Montani, Josiane Seydoux
FEBS letters - 2002 -
Susanna Iossa, Maria Pia Mollica, Lillà Lionetti, Raffaella Crescenzo, Monica Botta, Sonia Samec, Giovanni Solinas, Davide Mainieri, Abdul G Dulloo, Giovanna Liverini
Pflügers Archiv : European journal of physiology - 2002 -
Giovanni Solinas, M Motto
BioTechniques - 1999 -
F Magaraggia, Giovanni Solinas, G Valle, G Giovinazzo, I Coraggio
Plant molecular biology - 1997