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  4. Karin Manhem

Karin Manhem

Professor Emerita

Department of Molecular and Clinical Medicine
Mail
karin.manhem@gu.se
Visiting address
Medicinkliniken
³Òö³Ù±ð²ú´Ç°ù²µ
Postal address
SU Sahlgrenska
41345 ³Òö³Ù±ð²ú´Ç°ù²µ

About Karin Manhem

Main Research


Cardivascular prevention with focus on hypertension. Registry- and cohortstudies on hypertension and related diseases.

High blood pressure (hypertension), the most significant risk factor for death worldwide according to WHO is the main focus for our research. Despite cost-effective drugs, the majority of individuals with hypertension are still not well-treated. At present we study hypertension and its complications via two large registers created within the framework of primary health care in Sweden. In the Swedish Primary Care Cardiovascular Database (SPCCD) (n = 74751, mean age 69 +/- 13 years, 56% women) individual clinical patient data from 48 medical centers in patients with high blood pressure (collected from 2001 to 2008 with follow-up to 2013) are linked to the Medical register, National Board of the patient - and the cause of death records and Statistics Sweden's population register. Another large register, QRegPV , (Primary Care in the region of Västra Götaland) has a similar structure with linkage to national registers. Our scientific questions at present include how cardiovascular morbidity in men and women with hypertension is affected by the type of treatment and achieved blood pressure. In particular we focus on the effect of hypertension and its treatment on fractures, stroke, atrial fibrillation, diabetes and metabolic disturbances. Finally we study patients with severe hypertension (resistant hypertension).


Group Members

  • Kristina Bengtsson Boström, Associated professor, specialist in general practise Närhälsan Billingen vÃ¥rdcentral och Närhälsan FoU primärvÃ¥rd FoU-centrum Skaraborg
  • Per Hjerpe, PhD, specialist in general practise, Närhälsan Norrmalm VÃ¥rdcentral och Närhälsan FoU primärvÃ¥rd FoU-centrum Skaraborg
  • Andersson Björn, Associated professor, specialist in internal medicine, chief physician Omr 6, Medklin, SU/Sahlgrenska
  • Clara Hjalmarsson, PhD, specialist in internal medicine and cardiology, chief physician, Sahlgrenska Universitetssjukhuset/ VO Kardiologi
  • Anna-Clara Collén, PhD, specialist in internal medicine, chief physician Med Klin SU/Östra
  • Charlotta Ljungman, PhD,specialist in internal medicine and cardiology, chief physician, Kardiologen Sahlgrenska universitetssjukhuset
  • Lina Holmqvist, PhD, specialist in internal medicine, Sahlgrenska Universitetssjukhuset/Sahlgrenska, Medicinkliniken
  • Georgios Mourtzinis, PhD student, specialist in internal medicine and cardiology, chief physician, Sahlgrenska Universitetssjukhuset/Medicin- och akutverksamhet Mölndal
  • Tove Bokrantz, PhD student, resident in general practise, Carlanderska Sjukhuset


Key Publications

  • Ljungman C, Kahan T, Schiöler L, Wettermark B, Boström KB, Hasselström J, Hjerpe P, Manhem K. Blood Press. 13:1-9. doi: 10.1080/08037051.2017.1290503. [Epub ahead of print] (2017)
  • Qvarnström M, Kahan T, Kieler H, Brandt L, Hasselström J, Boström KB, Manhem K, Hjerpe P, Wettermark B. Medicine (Baltimore). 95(40):e4908. (2016)
  • Bokrantz T, Ljungman C, Kahan T, Boström KB, Hasselström J, Hjerpe P, Mellström D, Schiöler L, Manhem K. J Hypertens. 35(1):188-197. (2017)
  • Holmqvist L, Boström KB, Kahan T, Schiöler L, Hasselström J, Hjerpe P, Wettermark B, Manhem K. J Am Soc Hypertens. 10(11):838-846. doi: 10.1016/j.jash.2016.08.008. (2016)
  • Thunström E, Manhem K, Yucel-Lindberg T, Rosengren A, Lindberg C, Peker Y. Ann Am Thorac Soc. 13(11):2002-2011. (2016)
  • Adamsson Eryd S, Gudbjörnsdottir S, Manhem K, Rosengren A, Svensson AM, Miftaraj M, Franzén S, Björck S. BMJ. 4;354:i4070. doi: 10.1136/bmj.i4070. (2016)
  • Thunström E, Manhem K, Rosengren A, Peker Y. Am J Respir Crit Care Med. 1;193(3):310-20. doi: 10.1164/rccm.201505-0998OC. (2016)
  • Collén AC, Johansson MC, Guron CW, Gustafsson H, Manhem K. J Hum Hypertens. 29(11):702-4. doi: 10.1038/jhh.2015.68. (2015)
  • Jansson S, Fredén Lindqvist J, Manhem K, Nilsson O, Rosén T, Herlitz H. Am J Kidney Dis. 65(6):A17-9. doi: 10.1053/j.ajkd.2015.01.027. (2015)
  • Collén AC, Gustafsson H, Hellgren M, Schiöler L, Bexander L, Manhem K. Hypertens Pregnancy. 34(1):116-24. doi: 10.3109/10641955.2014.988348. (2015)
  • Ljungman C, Kahan T, Schiöler L, Hjerpe P, Hasselström J, Wettermark B, Boström KB, Manhem K. J Am Soc Hypertens. 8(12):882-90. doi: 10.1016/j.jash.2014.08.015. (2014)
  • Ljungman C, Kahan T, Schiöler L, Hjerpe P, Wettermark B, Boström KB, Manhem K. J Hum Hypertens. 29(6):385-93. doi: 10.1038/jhh.2014.100. (2015)