Marcus Svedberg - Monitoring cystic fibrosis lung disease in children - Clinical utility and associations between functional and structural methods
On September 2, Marcus Svedberg defended his thesis for Doctor of Medical 91̽»¨ at the Institute of Clinical 91̽»¨s, Sahlgrenska Academy, in the research subject of Paediatric.
The title of the thesis is: Monitoring cystic fibrosis lung disease in children - Clinical utility and associations between functional and structural methods
Abstract
Background: Cystic Fibrosis (CF) is an inherited progressive disease that causes severe damage to the airways and other organs of the body. Many methods are available to track CF lung disease but longitudinal data are needed to better understand the clinical utility and associations between different methods. The main aim of this doctoral thesis was to analyse and compare longitudinal data from lung function tests and image tests in children with CF.
Methods: In study I children aged 6–17 years attending Gothenburg’s CF clinic underwent multiple breath washout examinations, spirometry tests and a clinical stability assessment every 3rd month over a period of 1 year. Variability of the outcome parameters were analysed. In study II–IV 75 children aged 0–17 years underwent multiple breath washout examinations, spirometry tests, chest computer tomography (CT) and chest x-ray examinations between 1996–2016 at Gothenburg CF centre. Longitudinal trends and associations between outcome measures were analysed together with the effect of respiratory infections and other confounding factors.
Results: A total of 25 children completed a total of 107 visits of which 104 visits had complete data available in study I. The relative change in lung clearance index and FEV1% was +-17% (95th percentile) at clinical stable visits. In study II–IV a total of 75 participants with CF were included together with a healthy cohort of 140 children aged 0–17 years. Children with CF underwent lung functions tests and image tests and the healthy cohort only underwent multiple breath washout examinations. Study II demonstrated that intermittent and chronic infections were associated with an increased progression rate of structural lung disease measured with chest CT. Study III demonstrated associations between longitudinal LCI and the extent and progression rate of structural lung damage assessed with chest CT. The Lung clearance index was more sensitive than chest x-rays to detect early CF lung disease in study IV. The combined results of a normal chest x-ray and a normal lung clearance index were associated with a low extent of lung damage assessed with chest CT.
Conclusions: Multiple breath washout is a sensitive method to detect early CF lung disease. Lung function and imagine tests captured different dimensions of CF lung disease. The use of multiple methods in clinical practice provides a more robust assessment of CF lung disease than using either measure alone.
More information about the illustration at the top
Illustration: Figure 1 from page 8 in the thesis
Schematic overview of the procedure multiple breath washout using nitrogen (left picture) and sulphur hexafluoride (SF6) as an inert gas (right picture). No washout phase is needed when using nitrogen as an inert gas.
Reprinted with permission of the American Thoracic Society. Copyright 2022 ATS. Subbarao et al. Ann Am Thorac Soc. 2017 Jan;14(1):145.
Supervisor: Anders Lindblad
Co-Supervisor: Per Gustafsson
Opponent: Mirjam Stahl, Charité Universitätsmedizin Berlin, Tyskland
Examining Committee: Anders Elfvin, Lena Hjelte och Ã…se Johnsson