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  4. Erik Lekholm

Erik Lekholm

Professor

Department of Medical Biochemistry and Cell biology
Mail
erik.larsson@gu.se
Fax
+46 31-41 61 08
Visiting address
Medicinaregatan 9A
41390 Göteborg
Postal address
Box 440
405 30 Göteborg

About Erik Lekholm

Erik Larsson Lekholm is a Professor of Bioinformatics at the Institute of Biomedicine.

More information

Larsson Lekholm Research Group at the Dept. of Medical Biochemistry & Cell Biology.

Select publications

Elliott K, Singh VK, Bäckerholm A, Ögren L, Lindberg M, Soczek KM, Hoberg E, Luijts T, Van den Eynden J, Falkenberg M, Doudna J, Ståhlberg A, Larsson E. Mechanistic basis of atypical TERT promoter mutations. Nature Communications. 2024 Nov 18;15(1):9965.

Elliott K, Singh VK, Boström M, Larsson E. Base-resolution UV footprinting by sequencing reveals distinctive damage signatures for DNA-binding proteins. Nature Communications. 2023 May 11;14(1):2701.

Boström M, Larsson E. Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer. Nature Communications. 2022 Nov 17;13(1):7023.

Elias E, Ardalan A, Lindberg M, Reinsbach SE, Muth A, Nilsson O, Arvidsson Y, Larsson E. Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine. Nature Communications. 2021 Nov 4;12(1):6367

Elliott K, Larsson E. Non-coding driver mutations in human cancer. Nature Rev Cancer. 2021 Aug;21(8):500-509. (review)

Van den Eynden J, Jiménez-Sánchez A, Miller ML, Larsson E. Lack of detectable neoantigen depletion signals in the untreated cancer genome. Nature Genetics. 2019 Dec;51(12):1741-1748.

Lindberg M, Boström M, Elliott K, Larsson E. Intragenomic variability and extended sequence patterns in the mutational signature of ultraviolet light. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20411-20417.

Persson Ö, Muthukumar Y, Basu S, Jenninger L, Uhler JP, Berglund AK, McFarland R, Taylor RW, Gustafsson CM, Larsson E*, Falkenberg M*. Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions. Nature Communications. 2019 Feb 15;10(1):759.

Alaei-Mahabadi B, Bhaduryb J, Karlsson JW, Nilsson JA, Larsson E. Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers. Proc Natl Acad Sci U S A. 2016 Nov.

Ashouri A, Sayin VI, Van den Eynden J, Singh SX, Papagiannakopoulos T, Larsson E. Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events. Nature Communications. 2016 Oct 25;7:13197

Fredriksson NJ, Ny L, Nilsson JA, Larsson E. Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types. Nature Genetics. 2014 Dec;46(12):1258-63

Tang K, Alaei-Mahabadi B, Samuelsson T, Lindh M, Larsson E. The landscape of viral expression and host gene fusion and adaptation in human cancer. Nature Communications. 2013 4:2513